Shellac- a natural carrier for colon targeting of indomethacin using hot melt extrusion

Indomethacin (IND) is one of the supporting drug candidates for colonic targeting but it belongs to BCS class II category presenting a challenge in optimal at site. To overcome this challenge, we sought prepare pH-dependent soluble ternary solid dispersion (SD) IND improved solubility and dissolution rate colon without need coating. The current study focuses on preparation binary SDs API with shellac (SSB 55) Eudragit FS 100 (EFS) mixtures IND, SSB 55 together new grade HPMC (A15). Respective were prepared via HME achieve gastric protection performance including maintenance supersaturation. characterized tested in-vitro using pH shift method from 1.1, 5.5, 6.8, 7.4. A extrudate 55, A15 showed below 5.5 complete release 99.5% 7.4 compared neat extrudates IND-A15, IND-SSB IND-EFS. It was attributed an increased level intermolecular interaction confirmed by ATR-IR studied stability. found that mixture containing hydrogen bonding present, which resulted mixtures. Therefore, proved be promising concept future development poorly drugs.